Skin Boosters Explained: Profhilo vs Rejuran vs Vitaran
What each booster does, the concern it suits, and how to layer them safely.
Quick answer
Skin Booster: what to know first
Skin booster is a broad category, not one interchangeable treatment. Hyaluronic acid, polynucleotides and collagen-stimulating injectables differ in composition, intended role, evidence and recovery, so the choice should start with the skin concern and a medical assessment rather than the product name alone.
- Suitable for
- People prioritising hydration, early texture change or fine lines after the cause is assessed
- Discuss first
- Discuss pregnancy or breastfeeding, infection, allergies, medicines, bleeding risk and previous injectables
- Discomfort
- Brief stinging or pressure at multiple injection points; topical anaesthetic may be considered
- Downtime
- Small bumps, redness, swelling or bruising may last from hours to a few days
- When change may be noticed
- Change is gradual and varies by product, plan and individual response
"Skin booster" is an umbrella term, and the three most-asked-about names — Profhilo, Rejuran and Vitaran — actually do quite different things. Choosing well comes down to your main concern: hydration, repair, firmness or glow. Here's a clear, honest breakdown.
What is a skin booster?
Unlike filler, a skin booster isn't about adding shape or volume in one spot. It's microdroplets of hydrating or regenerative ingredients placed across an area to improve skin quality from within — deeper hydration, better elasticity, smoother texture and a healthy glow. Think of it as nourishing the canvas rather than reshaping it.
Profhilo — bio-remodelling hyaluronic acid
Profhilo uses one of the highest concentrations of pure hyaluronic acid, spread through tissue to deeply hydrate and stimulate elastin and collagen — a "bio-remodelling" effect. Best for overall skin laxity, crepey texture and a firmer, dewier look, often on the face and neck. Typically two initial sessions a month apart.
Rejuran — polynucleotide (PN) repair
Rejuran is a 2% polynucleotide (PN) injectable, made from purified DNA fragments derived from salmon, which support skin repair, calm inflammation and improve resilience and fine texture. People often choose it for dull, tired or sensitised skin, fine lines and post-acne texture. Usually a short series spaced a few weeks apart.
Vitaran — polynucleotide (PN) hydration & glow
Vitaran is also a 2% polynucleotide (PN) booster — very similar in composition to Rejuran — focused on deep hydration, skin-quality repair and a luminous, healthy-looking finish. It's a popular "glow" choice and a gentle complement after treatments like laser, especially when your main goal is plump, radiant, well-hydrated skin.
Read the doctor-reviewed Vitaran 2% PN guide in Asok
Which should you choose?
A simple way to decide by main goal: firmness & bounce → Profhilo (hyaluronic acid); repair, resilience or hydration & glow → a polynucleotide (PN) booster such as Rejuran or Vitaran, which share the same 2% PN base and are chosen by formulation and your skin's needs. They aren't mutually exclusive — a doctor may stage more than one across a few months. (Hori also offers Belotero Revive, an HA hydrating booster, when it's the better fit.)
| Comparison topic | Profhilo | Rejuran | Vitaran |
|---|---|---|---|
| Core | Pure HA | 2% PN (salmon) | 2% PN |
| Best for | Laxity, firmness | Repair, fine texture | Hydration, glow |
| Feel | Firmer, dewy | Calmer, resilient | Plump, radiant |
Indicative only — your doctor confirms suitability, product and schedule at consultation.
Physician decision lens
The product name comes after the skin assessment
A useful consultation does not begin by asking which booster is “best”. It first separates dehydration and texture from laxity, volume loss or active skin disease, because those findings may need a different method—or no injection yet.
- What is the single priority: hydration, texture, fine lines, firmness or volume?
- Are there active rashes, infection, recent procedures, previous injectables, allergies, medicines or bleeding concerns?
- Which area is being treated, how much downtime is acceptable, and how will the same conditions be reviewed?
- Would skincare, a device, another injectable category or observation answer the concern more directly?
The short version
- Boosters improve skin quality from within — they don't reshape like filler.
- Profhilo = HA for firmness; Rejuran & Vitaran = 2% polynucleotide (PN) for repair, hydration & glow.
- Best matched to your concern by a doctor — and often staged together.
Frequently asked questions
Skin booster vs filler — what's the difference?+
Filler adds shape or volume in a specific spot; a booster spreads hydrating or regenerative ingredients over an area to improve overall skin quality, not contour.
Which is best for glowing skin?+
Vitaran is a popular choice when the goal is hydration and a luminous finish. Rejuran also helps tired, dull skin look healthier. Your doctor will match it to your skin.
Is there downtime?+
Usually minimal — small injection points and occasional brief bumps or bruising that settle within a day or two. Most people return to normal activities quickly.
Can I combine them with laser or HIFU?+
Yes, and they often complement each other — boosters restore quality and glow while energy devices lift and tighten. Your doctor will sequence them safely.
How long do results last?+
It varies by product and skin, commonly around several months. A short initial series followed by occasional maintenance keeps the quality going.
