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Skin Quality · Bio-remodelling

Profhilo Explained: Bio-Remodelling for Firmer, Bouncier Skin

Why the "5-point technique" matters, who it suits, and what it will not do.

Hori Medical TeamReviewed by Dr. Peerapol6 min readJul 2026

Quick answer

What should you know before considering Profhilo?

Profhilo is an injectable stabilised hyaluronic-acid product intended to support hydration and skin quality, not to create facial contour like conventional filler. A doctor should first decide whether the concern is dehydration, texture, laxity or volume loss because each may need a different option. Suitability, injection points, treatment course and risk vary by anatomy and medical history.

Suitable for
Selected dehydration, crepey texture or early elasticity concerns when added facial volume is not the main goal.
What to expect
Hydration and texture changes are gradual, vary between individuals and should be reviewed after the planned course.
Risks
Raised injection points, redness, swelling or bruising may occur; infection and vascular complications are uncommon but require prompt assessment.
Downtime
Small raised points and mild swelling may remain from several hours to a few days; recovery varies.
When to see a doctor
Before treatment to identify the main concern, and urgently for severe pain, blanching, visual symptoms, worsening swelling or infection signs.
What Is Profhilo? HA Bio-Remodelling Guide at Hori Clinic Bangkok

Profhilo sits in its own category. It is hyaluronic acid, but engineered to spread and remodel rather than fill — one of the highest HA concentrations available in aesthetics, placed at just five points per side of the face. The result people describe: skin that feels firmer, bouncier and quietly more youthful.

What is Profhilo?

Profhilo is an injectable of ultra-pure, high-concentration hyaluronic acid (64 mg / 2 ml) with no chemical cross-linking agent. Instead of holding a shape like filler, it is thermally stabilised so it flows through the skin layer, hydrating deeply and signalling fibroblasts to produce new collagen and elastin — a process called bio-remodelling.

The signature BAP (Bio Aesthetic Points) technique uses five anatomically-safe points on each side of the face. Fewer punctures, even spread, minimal downtime.

How it differs from filler and other boosters

Filler shapes a specific spot. PN boosters (Rejuran, Vitaran) repair and hydrate. Profhilo targets laxity — the overall firmness and elasticity of the skin envelope. That is why doctors often describe it as "for skin that has started to feel loose or deflated, but doesn't need volume".

They are not competitors — many yearly plans stage Profhilo for firmness with a PN booster for repair, or with HIFU/RF for deeper lifting.

The standard course and what to expect

The protocol is 2 sessions, 4 weeks apart (2 ml each). Hydration shows within days; firmness and elasticity build over 4–8 weeks after the second session. A single top-up every 6 months or so maintains the effect.

Expect small bumps at the five points for a few hours up to a day — this is the product spreading, and it is normal.

Who gets the most from Profhilo

  • Skin that feels "looser" or less bouncy in the last few years
  • Dry, crepey texture on cheeks, jawline or neck
  • People who want improvement without a "done" look
  • Ages ~30+ as prevention-plus, or older as part of a lifting plan

The short version

  • Profhilo = high-dose HA that remodels — firmness and elasticity, not volume.
  • Standard course: 2 sessions 4 weeks apart, top-up ~every 6 months.
  • Pairs well with PN boosters and HIFU/RF in a yearly plan.

Frequently asked questions

Is Profhilo a filler?+

No. It is HA without cross-linking, designed to spread and stimulate rather than hold shape. It will not change your facial contours.

Where can it be injected?+

Most commonly the face (5 points per side); also the neck, and off-face areas like hands depending on assessment.

How long does it last?+

After the 2-session course, most people maintain results with a session every ~6 months. Collagen benefits persist beyond the HA itself.

Profhilo or Rejuran first?+

Depends on your main concern: laxity and crepiness suit Profhilo; weak, irritated, post-acne skin suits PN first. A doctor can stage both across the year.

Is there downtime?+

Minimal — visible bumps at the injection points for a few hours to a day, occasional small bruise. Most return to normal life immediately.

If you are comparing options

What Is Profhilo? HA Bio-Remodelling Guide at Hori Clinic Bangkok

Medical review

Dr. Peerapol Riawraengsattha (Dr. Lhong)

Anesthesiology · Aesthetic Medicine · Thai medical licence 58253

Sources used

We used peer-reviewed sources for this article. Your result and recovery may be different from someone else’s, so use this page to prepare questions rather than predict an outcome.

  1. Ghatge AS, Ghatge SB. The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review. Clin Cosmet Investig Dermatol. 2023;16:891-899. doi:10.2147/CCID.S404248
  2. Bezpalko L, Filipskiy A. Clinical and Ultrasound Evaluation of Skin Quality After Subdermal Injection of Two Non-Crosslinked Hyaluronic Acid-Based Fillers. Clin Cosmet Investig Dermatol. 2023;16:2175-2183. doi:10.2147/CCID.S402409

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