How was the study designed?
The prospective interventional study was conducted by the Department of Dermatology, Faculty of Medicine Siriraj Hospital. Sixteen adults with atrophic acne scars completed three monthly treatments using sequential Moveo scanning and fractional stamping modes. Outcomes were checked at baseline and 1, 3 and 6 months after the third session.
The study measured the Goodman and Baron quantitative scar score, Antera 3D texture and scar volume, blinded photograph grading, participant ratings, pain and adverse events. It did not include an untreated or alternative-treatment comparison group.
What changed at 6 months?
- Mean Goodman and Baron score decreased 14.5%, from 19.81 to 16.94.
- Antera 3D measurements showed statistically significant improvement in texture and scar volume.
- Blinded evaluators rated at least 25% improvement in 50% of participants.
- Participants themselves reported at least 25% improvement in 69% of cases.
These outcomes were not the same as complete scar removal. The clinician and participant ratings also differed, which is why standardised photography and objective follow-up matter.
Were there pigmentary side effects?
No serious complication was reported, but “no pigment risk” would be inaccurate. Two participants had a temporary acne flare, one developed a superficial scab that resolved within 3 days, and one developed linear hypopigmentation on the forehead after the first session. The paper reports that the hypopigmentation faded by 6 months.
A small study cannot reliably detect uncommon harms. Fitzpatrick type, recent sun exposure, active inflammation, previous pigment change and settings still need individual assessment.
What does this mean for choosing acne-scar treatment?
The study supports considering fractional 675 nm as a non-ablative option for selected atrophic scars in Asian skin, but it does not show that it is superior to Subcision, fractional CO2, radiofrequency microneedling or other options. The scar structure remains the first decision point.
- Tethered rolling scars: may need Subcision to release the fibrous bands.
- Deep ice-pick scars: often require a more targeted approach than one laser alone.
- Shallower atrophic scars and texture: fractional 675 nm may be one component of a gradual remodelling plan.
Sources
- Nisagornsen P, et al. Prospective Evaluation of a Fractional 675-nm Nonablative Laser for Atrophic Acne Scars in Fitzpatrick Skin Types III–IV. Lasers in Surgery and Medicine. 2025.
- Magni G, et al. Laser emission at 675 nm: in vitro study evidence of a promising role in skin rejuvenation. Regenerative Therapy. 2023.
This article summarises published research for consultation preparation. It is not a diagnosis or a promise of outcome.
